RENAL HEMODYNAMIC AND TUBULAR TRANSPORT EFFECTS OF NITRENDIPINE

  • 1 January 1985
    • journal article
    • research article
    • Vol. 105  (4) , 498-503
Abstract
Nitrendipine, a 1,4-dihydropyridine derivative, is a new Ca entry blocker with marked antihypertensive effects. Because relatively few data are available regarding its renal effects, the drug''s action on renal hemodynamics and electrolyte excretion was studied in normal male volunteers. During sustained water diuresis, 5-10 mg nitrendipine given orally caused an increase in urine flow rate and a modest but consistent increase in Na excretion (from 1.0% to 2.2% of filtered load, P < 0.01). Furthermore, both solute-free water clearance and percentage of free water excreted rose (from 10.1 .+-. 0.6 ml/min to 12.0 .+-. 0.8 ml/min and from 8.7% .+-. 0.5% to 10.5% .+-. 1.1%, respectively, P < 0.05 in each case). In addition, during the peak effect of the drug on Na and free water excretion, there was no consistent change in either glomerular filtration rate or effective renal plasma flow. Nitrendipine was also phosphaturic and calciuric but did not alter acid excretion. When administered to subjects with hydropenia receiving hypertonic saline infusion, the drug had no effect on solute-free water reabsorption. These results were interpreted to indicate that nitrendipine has direct tubular effects on renal electrolyte transport and that the locus of these effects is probably the proximal tubule. Thus, nitrendipine appears to differ from other Ca channel blockers in that it does not reduce glomerular filtration rate and is mildly natriuretic, rather than Na retentive.

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