EXPERIMENTAL URIC ACID NEPHRITIS IN THE RABBIT
Open Access
- 1 June 1957
- journal article
- research article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 105 (6) , 615-622
- https://doi.org/10.1084/jem.105.6.615
Abstract
Experimental uric acid lesions in the kidney of the rabbit have been reinvestigated using the technique of miscrodissection for location of lesions. The maximal initial lesion was found to occur in the first part of the collecting, and not in the ascending Henle and the distal convoluted tubule. Such lesions were only produced by very high dosage (approximately 0.5–1 gm. per kg.). It was concluded that the argument by analogy with the uric acid lesion cannot be used to support a hypothetical toxic damage to the segments of ascending Henle and the distal convolution in the crush syndrome.Keywords
This publication has 5 references indexed in Scilit:
- THE PATHOGENESIS OF ACUTE RENAL FAILURE ASSOCIATED WITH TRAUMATIC AND TOXIC INJURY. RENAL ISCHEMIA, NEPHROTOXIC DAMAGE AND THE ISCHEMURIC EPISODE 1Journal of Clinical Investigation, 1951
- Hemoglobinuric Nephrosis in Traumatic ShockAmerican Journal of Clinical Pathology, 1947
- The renal lesion in traumatic anuriaThe Journal of Pathology and Bacteriology, 1942
- Experimental phosphate nephritis in the ratThe Journal of Pathology and Bacteriology, 1941
- Experimental uric acid nephritisThe Journal of Pathology and Bacteriology, 1926