Chromatographic Optical Resolution on Polysaccharides and Their Derivatives

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Abstract
Cellulose and other polysaccharides have been known to exhibit chiral recognition properties for along time. Microcrystalline cellulose triacetate, cellulose triacetate with a particular morphology, was found to have excellent chiral properties over ten years ago. Recently, a new kind of packing material, utilizing cellulose esters has been developed, to resulting in numerous examples of optical resolution. The history of utilizing polysaccharides for the purpose of optical resolution will be briefly described and the typical examples of successful optical resolutions will be summarized. Though the mechanism of chiral recognition by polysaccharide derivatives is not known, much interesting information was obtained, the participation of crystalline lattice, the morphology and the ability of chiral recognition, the nature of the adsorptive interaction, etc. will be discussed.