Studies of the Renal Erythropoietic Factor Using a Hemagglutination-Inhibition System

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Abstract
A hemagglutination-inhibition system utilizing gamma-globulins extracted from anti-ESF serum for the determination of erythropoietin (ESF) is reported. Use of this technique showed that the renal erythropoietic factor (REF) is different immunochemically from ESF. Small but detectable levels of ESF were found in normal serum and the incubation of REF with serum resulted in the generation of ESF. The small increases in red cell 59Fe incorporation noted in assay mice treated with the REF alone is probably due to the endogenous production of the ESF.

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