Immunoadsorption for Removal of a and B Blood-Group Antibodies

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Abstract
ABO blood-group incompatibility between donor and recipient constitutes an obstacle to bone-marrow transplantation unless some method of removing the risk of hemolysis is used. Hemagglutinins in the recipient's plasma are capable of reacting with A or B antigens present on red cells in the donor's marrow. However, Gale1 and Buckner2 and their colleagues have carried out successful transplantations despite major ABO incompatibility by performing repeated plasma exchanges before infusing the marrow. This approach is effective but uses large quantities of a valuable blood product and exposes the recipient to additional risks of hepatitis and other transmissible disease. Thus, alternative methods . . .
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