The α-bromoester-imine condensation promoted by zinc-trimethylchlorosilane: a stereospecific short formal synthesis of (±)-carbapenem antibiotics and related compounds
- 1 January 1989
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 2,p. 74-76
- https://doi.org/10.1039/c39890000074
Abstract
Ethyl bromoacetate reacts with imines in the presence of zinc activated by trimethylchlorosilane to give high yields of 3-unsubstituted β-lactams.Keywords
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