Acetylator Phenotype in Patients with Breast Cancer

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Abstract
Acetylator phenotype was established by the method of Evans in 41 patients with breast cancer and 38 female controls. The results showed that the group of patients with advanced breast cancer included relatively more rapid-acetylating females (68% of rapid and 32% of slow acetylators) as compared with controls (37% of rapid and 63% of slow acetylators). The level of acetylating in rapid and slow acetylating breast cancer patients were higher than in corresponding groups of controls. A possible association between changes in the activity of acetylation in breast cancer patients and the genetic regulation processes in tumor growth is discussed.