From classical antimalarial drugs to new compounds based on the mechanism of action of artemisinin
- 1 July 2001
- journal article
- Published by Walter de Gruyter GmbH in Pure and Applied Chemistry
- Vol. 73 (7) , 1173-1188
- https://doi.org/10.1351/pac200173071173
Abstract
A short review of the antimalarial drugs currently used in human clinics is reported. The molecular aspect of the different possible mechanisms of action of artemisinin is documented, including recent data on heme alkylation. The preparation and the in vitro antimalarial activity of new modular molecules named "trioxaquines" are also presented.Keywords
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