Human low-dosage parenteral methotrexate therapy. A controlled toxicity study

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Abstract
Methotrexate was administered intramuscularly to 10 patients with severe psoriasis and 1 patient with a generalized erythroderma. All patients were observed carefully for toxicity by the use of a number of laboratory procedures. Clinical improvement was compared with a control group receiving placebo injections and standard dermatologic topical therapy. The results indicate that methotrexate administered intramuscularly is a therapeutically beneficial drug; however, it is a potentially toxic drug, unless precautions are observed.