Synthesis of Novel Polyethers in a Geometrically Precise Conformation
- 12 August 1999
- journal article
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 1 (5) , 725-728
- https://doi.org/10.1021/ol990618h
Abstract
A convergent design for the preparation of a polyoxyethylene-based channel molecule is presented, and the synthesis of the key unit 2 required for the projected construction is described. The essential elements of the design included face to face oriented macrorings spaced by rigid trans-fused oxanes. The strategy combines conformational predictability of C-linked oxanyl systems and ring-closing metathesis for the synthesis of crown ethers with engineerable ion-binding abilities.Keywords
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