Acute Tryptophan Depletion. Part I: Rationale and Methodology
- 1 July 2005
- journal article
- review article
- Published by SAGE Publications in Australian & New Zealand Journal of Psychiatry
- Vol. 39 (7) , 558-564
- https://doi.org/10.1080/j.1440-1614.2005.01627.x
Abstract
Objective: Acute tryptophan depletion (ATD) is an experimental technique that has been widely used over the last decade to investigate the role of serotonin (5-HT) in a variety of disorders. This review, the first of two articles, describes the rationale behind this technique and provides detail on how it is applied in research settings. Method: The authors outline the development of this technique with reference to the seminal literature and more recent findings from neuroimaging and neuroendocrine studies. This is supplemented by the authors' clinical experience of over 5 years of continuous experimental work with this paradigm in over 50 subjects. Results: Acute tryptophan depletion is a method that significantly reduces central 5-HT in human subjects. Non-serotonergic explanations of the effects of ATD have not been confirmed, supporting the specificity of this method. Conclusions: The ATD technique is a valid method of manipulating central 5-HT levels. The second article in this series will review the application of ATD in depression, anxiety and other psychiatric conditions.Keywords
This publication has 53 references indexed in Scilit:
- Effects of normal meals rich in carbohydrates or proteins on plasma tryptophan and tyrosine ratiosThe American Journal of Clinical Nutrition, 2003
- Serotonin release varies with brain tryptophan levelsBrain Research, 1990
- Dieting reduces plasma tryptophan and alters brain 5-HT function in womenPsychological Medicine, 1990
- Neuroendocrine and behavioral effects of dietary tryptophan restriction in healthy subjectsLife Sciences, 1988
- Reduction of REM sleep by a tryptophan-free amino acid dietLife Sciences, 1979
- Parachlorophenylalanine Reversal of Tranylcypromine Effects in Depressed PatientsArchives of General Psychiatry, 1976
- Amino acid assignment to one of three blood-brain barrier amino acid carriersAmerican Journal of Physiology-Legacy Content, 1976
- Inhibition of Serotonin Synthesis by Para-Chlorophenylalanine in Patients with the Carcinoid SyndromeNew England Journal of Medicine, 1967
- Binding of Indole Analogues to Human Serum AlbuminPublished by Elsevier ,1965
- THE AMINO ACID REQUIREMENTS OF MANJournal of Biological Chemistry, 1954