Structure of α Form of l-Glutamic Acid. α-β Transition
- 1 January 1980
- journal article
- Published by Oxford University Press (OUP) in Bulletin of the Chemical Society of Japan
- Vol. 53 (1) , 30-35
- https://doi.org/10.1246/bcsj.53.30
Abstract
An X-ray analysis of the α form of l-glutamic acid, C5H9NO4, has been carried out. The space group is P212121 with a=7.068(1), b=10.277(1), c=8.755(1) Å and Z=4. The structure was solved by the direct method, and least-squares refinement using 855 reflexions led to the final R value of 0.034. The molecule is in a zwitter ion form, and there is a strong OH···O intermolecular hydrogen bond with the O···O distance of 2.578(2) Å. The conformation of l-glutamic acid in the α form is quite different from that in the β form. The occurence frequency in various crystal structures containing glutamic acid residues shows that the conformation in the β crystal is more stable and favourable than that in the α crystal. The transition of the α form to the β form of l-glutamic acid in the mother liquor and the conditions for obtaining the α crystals are discussed based on the crystal and molecular structures of the two polymorphs.Keywords
This publication has 14 references indexed in Scilit:
- The structure of a 1:1 mixed crystal of L-glutamic acid and L-pyroglutamic acid, C5H9NO4.C5H7NO3.H2O, and a refinement of the structure of pyroglutamic acid, C5H7NO3Acta Crystallographica Section B: Structural Science, Crystal Engineering and Materials, 1977
- X-ray studies of crystalline complexes involving amino acids. II. The crystal structure of L-arginine L-glutamateActa Crystallographica Section B: Structural Science, Crystal Engineering and Materials, 1977
- Complexes between Nucleotide Base and Amino Acid. III. Crystal Structure of 5-Bromocytosine:Phthaloyl-Dl-glutamic Acid Complex HemihydrateBulletin of the Chemical Society of Japan, 1977
- Complexes between Nucleotide Base and Amino Acid. II. Crystal Structure of 5-Bromocytosine : N-Tosyl-l-glutamic AcidBulletin of the Chemical Society of Japan, 1976
- Calcium-binding to α-amino acids: crystal structure of calcium L-glutamate trihydrateActa Crystallographica Section B: Structural Science, Crystal Engineering and Materials, 1974
- Precision neutron diffraction structure determination of protein and nucleic acid components. VIII: the crystal and molecular structure of the ?-form of the amino acidl-glutamic acidJournal of Chemical Crystallography, 1972
- STUDIES ON THE CONFORMATION OF AMINO ACIDSInternational Journal of Protein Research, 1971
- IUPAC-IUB Commission on Biochemical NomenclatureJournal of Molecular Biology, 1970
- The crystal structure of copper glutamate dihydrateActa Crystallographica, 1966
- The crystal structure of zinc glutamate dihydrateActa Crystallographica, 1966