The Effect of Corticosteroids on the Radiation Skin Reaction. A Random Trial to Assess the Value of Local Application of Prednisolone and Neomycin Ointment after X-ray Treatment of Basal Cell Carcinoma

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Abstract
A random trial was performed to compare the effect on the skin reaction of local application of Prednisolone and Neomycin ointment, Neomycin ointment, or no ointment after X-ray treatment of basal cell cancer in three groups of ten patients each. The area of moist desquamation was significantly lessened in the Prednisolone and Neomycin ointment group. It is suggested that topical application of a water miscible steroid and antibiotic ointment may be useful in clinical radiotherapy to sites such as the eye, groins and perineum and where a severe and troublesome skin reaction might be expected.

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