Demonstration of the difference in binding affinity between the two binding sites of the ristocetin A asymmetric dimer
- 1 January 1996
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Chemical Communications
- No. 1,p. 101-103
- https://doi.org/10.1039/cc9960000101
Abstract
The titration of 13C labeled N-acetyl-D-ala-D-ala with the glycopeptide antibiotics ristocetin A and eremomycin, monitored by 13C NMR spectroscopy, demonstrates that the two distinct binding sites of the ristocetin A asymmetric dimer have different affinities, whereas those of eremomycin show no detectable difference.Keywords
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