Cytoplasmic Tail-Dependent Localization of CD1b Antigen-Presenting Molecules to MIICs
- 19 July 1996
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 273 (5273) , 349-352
- https://doi.org/10.1126/science.273.5273.349
Abstract
CD1 proteins have been implicated as antigen-presenting molecules for T cell-mediated immune responses, but their intracellular localization and trafficking remain uncharacterized. CD1b, a member of this family that presents microbial lipid antigens of exogenous origin, was found to localize to endocytic compartments that included the same specialized subset of endosomes in which major histocompatibility complex (MHC) class II molecules are proposed to bind endocytosed antigens. Unlike MHC class II molecules, which traffic to antigen-loading endosomal compartments [MHC class II compartments (MIICs)] primarily as a consequence of their association with the invariant chain, localization of CD1b to these compartments was dependent on a tyrosine-based motif in its own cytoplasmic tail.Keywords
This publication has 26 references indexed in Scilit:
- A lysosomal targeting signal in the cytoplasmic tail of the beta chain directs HLA-DM to MHC class II compartments.The Journal of cell biology, 1995
- Interaction of Tyrosine-Based Sorting Signals with Clathrin-Associated ProteinsScience, 1995
- Assembly and intracellular transport of HLA-DM and correction of the class II antigen-processing defect in T2 cellsImmunity, 1994
- CDlb restricts the response of human CD4−8−T lymphocytes to a microbial antigenNature, 1992
- A novel di-leucine motif and a tyrosine-based motif independently mediate lysosomal targeting and endocytosis of CD3 chainsCell, 1992
- Segregation of MHC class II molecules from MHC class I molecules in the Golgi complex for transport to lysosomal compartmentsNature, 1991
- Intracellular transport of class II MHC molecules directed by invariant chainNature, 1990
- MHC class II-associated invariant chain contains a sorting signal for endosomal compartmentsCell, 1990
- Recognition of cluster of differentiation 1 antigens by human CD4−CD8>− cytolytic T lymphocyteNature, 1989
- Biochemical comparison of the T6 antigen and HLA-A,B antigensHuman Immunology, 1983