A marker for Stevens–Johnson syndrome
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- 1 April 2004
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 428 (6982) , 486
- https://doi.org/10.1038/428486a
Abstract
Stevens–Johnson syndrome and the related disease toxic epidermal necrolysis are life-threatening reactions of the skin to particular types of medication1,2,3. Here we show that there is a strong association in Han Chinese between a genetic marker, the human leukocyte antigen HLA–B*1502, and Stevens–Johnson syndrome induced by carbamazepine, a drug commonly prescribed for the treatment of seizures. It should be possible to exploit this association in a highly reliable test to predict severe adverse reaction, as well as for investigation of the pathogenesis of Stevens–Johnson syndrome.Keywords
This publication has 9 references indexed in Scilit:
- Pharmacogenetics goes genomicNature Reviews Genetics, 2003
- HLA DNA Typing and TransplantationImmunity, 2001
- Risk of Stevens-Johnson syndrome and toxic epider mal necrolysis during first weeks of antiepileptic therapy: a case-control studyThe Lancet, 1999
- Erythema multiforme, Stevens–Johnson syndrome and toxic epidermal necrolysis in northeastern MalaysiaInternational Journal of Dermatology, 1998
- Toxic epidermal necrolysis in a burns centre: A 6-year reviewBurns, 1996
- Medication Use and the Risk of Stevens–Johnson Syndrome or Toxic Epidermal NecrolysisNew England Journal of Medicine, 1995
- The Spectrum of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: A Clinical Classification.Journal of Investigative Dermatology, 1994
- HLA phenotypes and bullous cutaneous reactions to drugsTissue Antigens, 1986
- High Association of an HL-A Antigen, W27, with Ankylosing SpondylitisNew England Journal of Medicine, 1973