A Study on the Protective Action of 2,3-Dimercaptopropanol (BAL) on Radiation-Induced Changes in the Ovarian Follicles in Mice

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Abstract
Mice were irradiated internally with P32 (5 [mu]C/g.) and externally with roentgen rays (400 or 600 r). Some of the animals were treated with 2,3-dimercaptopropanol (BAL). The animals were sacrificed after 4 or 6 days. Follicular diams. in the ovaries were measured and grain countings were made on ovarian autoradiographs. Significant protection (estimated to be about 40%) was obtained with BAL in the p32_treated animals. No significant protection was obtained in the roentgen irradiated mice. This may be due to the fact that repeated injn. of BAL were given in the P32_ irradiated mice, and only one injn. in the roentgen irradiated mice. Treatment of radioisotope intoxication by sulfhydryls is suggested.