The Effects of Ascorbic Acid on Bactericidal Mechanisms of Neutrophils

1 August 1971

journal article
Published by Oxford University Press (OUP) in The Journal of Infectious Diseases

Vol. 124 (2) , 194-198
https://doi.org/10.1093/infdis/124.2.194

Abstract

Ascorbic acid inhibits both of the H₂O₂-myeloperoxidase-halide reactions which have been implicated in the bactericidal activity of neutrophils. Both iodination of zymosan in intact neutrophils and the decarboxylation of L-alanine by neutrophil sonicates do not take place in the presence of 0.01 m ascorbic acid. Despite the inhibition of these reactions, the clearance of Staphylococcus aureus and Escherichia coli in intact phagocytes is normal. The mechanism by which ascorbic acid inhibits H₂O₂-myeloperoxidase-halide reactions is unknown.

Keywords

ALANINE
NEUTROPHILS
BACTERICIDAL
DECARBOXYLATION
IODINATION
AUREUS
ASCORBIC ACID INHIBITS

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