Regulation of cardiac hypertrophy by intracellular signalling pathways
Top Cited Papers
- 1 August 2006
- journal article
- review article
- Published by Springer Nature in Nature Reviews Molecular Cell Biology
- Vol. 7 (8) , 589-600
- https://doi.org/10.1038/nrm1983
Abstract
The mammalian heart is a dynamic organ that can grow and change to accommodate alterations in its workload. During development and in response to physiological stimuli or pathological insults, the heart undergoes hypertrophic enlargement, which is characterized by an increase in the size of individual cardiac myocytes. Recent findings in genetically modified animal models implicate important intermediate signal-transduction pathways in the coordination of heart growth following physiological and pathological stimulation.Keywords
This publication has 142 references indexed in Scilit:
- JNK1 is required to preserve cardiac function in the early response to pressure overloadBiochemical and Biophysical Research Communications, 2006
- Modulatory calcineurin-interacting proteins 1 and 2 function as calcineurin facilitatorsin vivoProceedings of the National Academy of Sciences, 2006
- Second nature: Biological functions of the Raf‐1 “kinase”FEBS Letters, 2005
- Histone Deacetylases 5 and 9 Govern Responsiveness of the Heart to a Subset of Stress Signals and Play Redundant Roles in Heart DevelopmentMolecular and Cellular Biology, 2004
- Calcium–calcineurin signaling in the regulation of cardiac hypertrophyBiochemical and Biophysical Research Communications, 2004
- The role of phosphoinositide-3 kinase and PTEN in cardiovascular physiology and diseaseJournal of Molecular and Cellular Cardiology, 2004
- ErbB2 Pathways in Heart and Neural DiseasesTrends in Cardiovascular Medicine, 2003
- Translating the Histone CodeScience, 2001
- HDAC4 deacetylase associates with and represses the MEF2 transcription factorThe EMBO Journal, 1999
- Targeting the Receptor-G q Interface to Inhibit in Vivo Pressure Overload Myocardial HypertrophyScience, 1998