Interaction of quaternary aromatic isoquinoline alkaloids with acetylcholinesterase from Electrophorus electricus

1 January 1985

journal article
Published by Institute of Organic Chemistry & Biochemistry in Collection of Czechoslovak Chemical Communications

Vol. 50 (4) , 978-983
https://doi.org/10.1135/cccc19850978

Abstract

Fluorescence data for the interaction of acetylcholinesterase (EC 3.1.1.7, ACHE) from Electrophorus electricus with berberine, 13-ethylberberine, coralyne, and chelerythrine have been presented. By a comparison with known inhibitors of acetylcholinesterase, tetramethylammonium and tacrine, the electrostatic interaction of quaternary alkaloids with the γ-anionic site of enzyme could be confirmed. During the interaction, two molecules of the ligand are bound to the molecule of the enzyme.

Keywords

BERBERINE
FLUORESCENCE DATA
ACETYLCHOLINESTERASE
ELECTROSTATIC
ACHE
ELECTROPHORUS ELECTRICUS
ALKALOIDS

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