In Vitro Studies of Netilmicin, a New Aminoglycoside Antibiotic
Open Access
- 1 June 1977
- journal article
- research article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 11 (6) , 1017-1020
- https://doi.org/10.1128/aac.11.6.1017
Abstract
Netilmicin, a semisynthetic derivative of sisomicin, was tested in vitro against 600 clinical bacterial isolates. At a concentration of 1.56 μg/ml, over 90% of gram-negative bacilli were inhibited. Netilmicin was substantially more active against isolates of Serratia marcescens and Enterobacter spp. than gentamicin, sisomicin, tobramycin, or amikacin. Isolates of Staphylococcus aureus (both penicillin G susceptible and resistant) were quite susceptible to netilmicin. Most isolates of Klebsiella spp. and Serratia spp. and some of the isolates of Pseudomonas aeruginosa that were resistant to gentamicin proved to be susceptible to netilmicin.Keywords
This publication has 6 references indexed in Scilit:
- Biological Activity of Netilmicin, a Broad-Spectrum Semisynthetic Aminoglycoside AntibioticAntimicrobial Agents and Chemotherapy, 1976
- Comparative Activity of Netilmicin, Gentamicin, Amikacin, and Tobramycin Against Pseudomonas aeruginosa and EnterobacteriaceaeAntimicrobial Agents and Chemotherapy, 1976
- In Vitro Comparison of Netilmicin, a Semisynthetic Derivative of Sisomicin, and Four Other Aminoglycoside AntibioticsAntimicrobial Agents and Chemotherapy, 1976
- Colonization with Gentamicin-Resistant Pseudomonas aeruginosa, Pyocine Type 5, in a Burn UnitThe Journal of Infectious Diseases, 1971
- Resistance of Gram-Negative Bacilli to GentamicinThe Journal of Infectious Diseases, 1971
- INFECTIONS DUE TO GRAM-NEGATIVE ORGANISMS: AN ANALYSIS OF 860 PATIENTS WITH BACTEREMIA AT THE UNIVERSITY OF MINNESOTA MEDICAL CENTER, 1958–1966Medicine, 1969