THE INFLUENCE; OF HEMODIALYSIS TREATMENT ON THE INJURIES OF THE CENTRAL NERVOUS SYSTEM IN UREMIA

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Abstract
Based on the clinical examination of 123 uremic patients, the majority subjected to hemodialysis, and on neurohistologic examination of the central nervous systems of 30 deceased patients from the same group, attention is called to those neuropsychiatric syndromes (apalllal syndrome, akinetic mutism, intensified clouding of consciousness in the course of dialysis, development of amentiform reactions) which have been encountered as complications apparently due to the treatment and which indicate an unfavorable course of the disease. Hemodialysis can by no means be regarded as an indifferent intervention. It imposes additional strain on the organism. Humoral changes occurring in its course (alteration in the osmotic state and pH level with subsequent increased disposition to cerebral edema, displacement of the liquor pH level towards the acidotic state) exert a severe influence on the cerebral blood vessels and lead occasionally to the described neuropsychiatric complications, especially in the presence of some vascular affection.

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