A Clostridium botulinum type B vaccine for prevention of shaker foal syndrome

Publisher Website
Google Scholar
Abstract
A toxoid was prepared from type B toxin of Clostridium botulinum by treatment with 0.6% formalin for 6 weeks. The toxoid was adsorbed to aluminum hydroxide and this vaccine was evaluated for safety in guinea pigs, mice and horses, and for immunogenicity in guinea pigs and horses. Neutralising antitoxin was demonstrated in adult horses receiving two 2 ml subcutaneous doses 6 weeks apart, and in a foal which suckled its vaccinated dam. Another vaccinated mare and the passively immunized foal were protected against subcutaneous injection of 1600 and 2000 mouse lethal doses of toxin per kg respectively.

This publication has 3 references indexed in Scilit: