Ventricular enlargement in schizophrenia: relationship to positive and negative symptoms

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Abstract
The clinical correlates of ventricular enlargement in schizophrenia were explored by comparing 16 patients with large ventricles (ventricles more than 1 SD above the control mean) with 16 patients with the smallest ventricles from a sample of 52 schizophrenic patients. Patients with ventricular enlargement showed some impairment in the sensorium and had a preponderance of negative symptoms (e.g., alogia, affective flattening, avolition, anhedonia), while those with small ventricles were characterized by positive symptoms (e.g., delusions, hallucinations, positive formal thought disorder, bizarre behavior). Combining a measure of brain structure with the clinical picture may provide a useful new approach to the classification of schizophrenia.

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