Efficient Synthesis of Deoxy and Dideoxy Sugars by a Thio-Mitsunobu Reaction on Unprotected Glycosides

Abstract
6-Deoxy-gluco- and 3,6-dideoxy-ribo-hexopyranosides were synthesized in two consecutive steps from unprotected β-glucopyranoside derivatives by a highly regioselective thio-Mitsunobu reaction and subsequent desulfurization. In contrast,the α-anomer reacted only at position 6.

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