Factors Influencing the Effect of Hemagglutinating Viruses on Tumor Cell Suspensions

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Abstract
Summary: Tumor inhibition has been demonstrated for four strains of influenza and two strains of NDV when these viruses are mixed with suspensions of either sarcoma 180 or Ehrlich carcinoma cells. Spontaneous elution has been demonstrated for only the strains of DNV. Cells from which the virus has eluted are incapable of being inhibited by fresh virus. Treatment of NDV by heat, ultrasonics, formalin or ultraviolet has resulted in the prompt loss of the tumor inhibitory power. The Lee strain of influenza virus heated to 56° C for 20 minutes and mixed with tumor cells retained the ability to inhibit tumor formation although its infectivity was greatly diminished. Although Lee virus and NDV treated with ultraviolet were incapable of inhibiting tumor growth, they prevented the adsorption of fully active virus. Cells treated with RDE failed to be inhibited when either NDV or influenza viruses were added. When inhibition had taken place by mixture of virus and cells the addition of RDE resulted in removal of the virus and tumor growth.

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