FURTHER STUDIES OF THE EFFECTS OF INSULIN ON THE METABOLISM OF VITAMIN C 1

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Abstract
The mechanism by which insulin causes a prompt fall in plasma and urinary vit. C levels of humans and dogs was investigated. Evidence is presented that the effect is only transient, that insulin has no effect on ascorbic acid in vitro, and does not increase the utilization of, or depress the synthesis of, ascorbic acid. Associated with the fall in plasma levels of vit. C after insulin injection there appears to be a rise in the WBC-platelet layer conc. of ascorbic acid. It is suggested that insulin causes a temporary redistribution of ascorbic acid in the body, involving an early passage of ascorbic acid from plasma and extracellular fluid into tissues, followed later by a return.