Relationship Between Central and Peripheral Serotonin Indexes in Depressed and Suicidal Psychiatric Inpatients
- 1 June 1992
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of General Psychiatry
- Vol. 49 (6) , 442-446
- https://doi.org/10.1001/archpsyc.1992.01820060022003
Abstract
• Serious suicidal behavior, affective disorders, and a variety of other psychopathologic behaviors and syndromes have been found to correlate with measures of the serotonin system. Clinical studies have employed a range of serotonin indexes, including the cerebrospinal fluid level of 5-hydroxyindoleacetic acid, the prolactin response to serotonin agonists, such as fenfluramine hydrochloride, and platelet serotonin-related proteins or serotonin content. Many of these indexes are correlated with suicidal behavior, but the interrelationship of these biologic measures has been uncertain. We studied the relationship of a series of serotonin indexes in patients in whom these measures were correlated with suicidal behavior. A positive correlation was found between cerebrospinal fluid 5-hydroxyindoleacetic acid and the maximal prolactin response to fenfluramine but not with platelet serotonin,receptor indexes. The fenfluramine-stimulated maximal prolactin response correlated with platelet serotonin2receptor number, particularly in older patients. We conclude that cerebrospinal fluid 5-hydroxyindoleacetic acid measurements cannot be replaced but can be complemented by less invasive procedures, such as a fenfluramine challenge test or platelet serotonin2measures, in the study of the relationship of the serotonin system to psychiatric disorders.Keywords
This publication has 11 references indexed in Scilit:
- No correlation between platelet imipramine binding and CSF5HIAA in neurosurgical patientsPsychiatry Research, 1990
- Effects of age and gender on CNS serotonergic responsivity in normal adultsBiological Psychiatry, 1990
- Relationship Between Serotoninergic Measures in Blood and Cerebrospinal Fluid Simultaneously Obtained in HumansJournal of Neurochemistry, 1990
- Evidence for the 5-HT Hypothesis of Suicide A Review of Post-mortem StudiesThe British Journal of Psychiatry, 1989
- Serotonergic Studies in Patients With Affective and Personality DisordersArchives of General Psychiatry, 1989
- Serotonergic Responsivity in Male Young Adults With Autistic DisorderArchives of General Psychiatry, 1989
- Circadian rhythms in mammalian neurotransmitter receptorsProgress in Neurobiology, 1987
- Simultaneous determination of 3-methoxy-4-hydroxyphenylglycol, 5-hydroxyindoleacetic acid, and homovanillic acid in cerebrospinal fluid with high-performance liquid chromatography using electrochemical detectionAnalytical Biochemistry, 1983
- Platelet MAO activity and monoamine metabolites in cerebrospinal fluid in depressed and suicidal patients and in healthy controlsPsychiatry Research, 1981
- A RATING SCALE FOR DEPRESSIONJournal of Neurology, Neurosurgery & Psychiatry, 1960