Bumetanide, a new loop diuretic

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Abstract
The effect of bumetanide on renal function has been compared with that o.ffurosemide and a placebo in a double‐blind study in 9 healthy young men. The sequence for oral administration of the drug was subjected to a random assignation based upon the Latin‐square methodology under three different conditions. (I) Normal hydration: The administration of bumetanide (2 mg) produced within the next 4 hr a diuresis comparable to that induced by 80 mg offurosemide. Urinary excretion of sodium, potassium, chloride, calcium, and uric acid also followed comparable patterns. Phosphaturia occurred only under bumetanide. The effect of bumetanide seemed longer lasting. (2) Water loading: The e.ffects o.f bumetanide andfurosemide were comparable with the exception of the phosphaturic effect induced by bumetanide. The action of both diuretics on the diluting segment of the nephron was well demonstrated by the marked depression of CH2O. (3) Water deprivation: The effects o.f the two diuretics were comparable, including depression of TCH2O. In none of these conditions did the placebo produce any significant effect.