STUDIES ON CHEMICAL CARCINOGENS .15. SYNTHESIS OF 4-(N-HYDROXY-N-METHYLAMINO)QUINOLINE 1-OXIDE AND ITS CARCINOGENIC ACTIVITY ON MICE

1 January 1978

journal article
research article

Vol. 69 (6) , 835-837

Abstract

4-(N-Hydroxy-N-methylamino)quinoline 1-oxide (N-Me-4-HAQO), the structure of which consists of a quinoline 1-oxide moiety involved in carcinogenic 4-nitroquinoline 1-oxide and an N-hydroxy-N-methylamino group involved in N-hydroxy-N-monomethylaminoazobenzene, was synthesized. It was potently carcinogenic in mice when injected s.c.

This publication has 1 reference indexed in Scilit:

HEPATIC-METABOLISM OF N-HYDROXY-N-METHYL-4-AMINOAZOBENZENE AND OTHER N-HYDROXY ARYLAMINES TO REACTIVE SULFURIC-ACID ESTERS
1976