Perfect Stereochemical Control in the Synthesis of syn-α-Methyl-β-hydroxy Thioesters by Asymmetric Aldol Reaction of Silyl Enol Ethers with Aldehydes
- 1 June 1989
- journal article
- research article
- Published by Oxford University Press (OUP) in Chemistry Letters
- Vol. 18 (6) , 1001-1004
- https://doi.org/10.1246/cl.1989.1001
Abstract
Perfect stereochemical control in the synthesis of syn-α-methyl-β-hydroxy thioesters are achieved by the asymmetric aldol reaction between silyl enol ether of S-ethyl propanethioate and aldehydes by the use of a chiral promoter consisted of chiral diamine coordinated tin(II) triflate and tributyltin fluoride.Keywords
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