Examination of Newly Synthesized 2-Chloroethyl-nitrosoureas on Rat Leukemia L 5222
- 1 January 1981
- journal article
- research article
- Published by S. Karger AG in Oncology
- Vol. 38 (1) , 39-42
- https://doi.org/10.1159/000225519
Abstract
The preterminal i.p. implanted rat leukemia L-5222 was used to test the chemotherapeutic activity of 10 newly synthesized nitrosoureas: ethylmethanesulfonato-CNU [chloroethylnitrosourea], acetamido-CNU, dihydroxypropyl-CNU, carboxyethyl-CNU, cyanoethyl-CNU, morpholino-CNU, piperidino-CNU, methylene-dioxybenzyl-CNU, methylene-3-pyridyl-CNU and methylene-4-pyridyl-CNU; their activity was compared against BCNU, CCNU, MeCCNU and hydroxyethyl-CNU. All compounds tested showed chemotherapeutic activity. MeCCNU was superior to all other compounds investigated. The predictive value for human tumors, obtained from study of a model that is highly sensitive to nitrosoureas, is discussed.This publication has 2 references indexed in Scilit:
- Chemotherapeutic Activity of New 2-Chloroethylnitrosoureas in Rat L5222 Leukemia: Comparison of Bifunctional and Water-Soluble Derivatives With 1,3-Bis(2-chloroethyl)-1-nitrosoureaJNCI Journal of the National Cancer Institute, 1978
- Some new congeners of the anticancer agent 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) synthesis of bifunctional analogs and water soluble derivatives and preliminary evaluation of their chemotherapeutic potentialZeitschrift für Krebsforschung und Klinische Onkologie, 1976