Ganciclovir Susceptibilities and Analysis of UL97 Region in Cytomegalovirus (CMV) Isolates from Bone Marrow Recipients with CMV Disease after Antiviral Prophylaxis
Open Access
- 1 August 1998
- journal article
- Published by Oxford University Press (OUP) in The Journal of Infectious Diseases
- Vol. 178 (2) , 531-534
- https://doi.org/10.1086/517467
Abstract
Ganciclovir susceptibilities and UL97 sequences were analyzed in 20 cytomegalovirus (CMV) isolates recovered from 15 bone marrow transplant recipients with active CMV infection after prophylaxis with acyclovir (group I; 12 isolates) or after acyclovir prophylaxis followed by ganciclovir therapy (group II; 8 isolates). All group I isolates were susceptible to ganciclovir. Five group II isolates were susceptible to ganciclovir, and 3 isolates (all from the same person) were resistant to ganciclovir (IC50 >12 μM). Ganciclovir resistance UL97 mutations were found in 4 group II isolates, including a ganciclovir-susceptible isolate obtained from 1 patient after 41 days of therapy with ganciclovir and 3 ganciclovir-resistant isolates obtained from another patient after 73, 116, and 132 days of treatment with ganciclovir. Ganciclovir-resistant CMV isolates may emerge rapidly in bone marrow transplant recipients who are treated with ganciclovir after receiving prophylaxis with acyclovir.Keywords
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