Evaluation of the Potential Carcinogenic and Co-Carcinogenic Action of Drugs

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Abstract
Carcinogenicity of organic Fe complexes, 5.04%, 9.5%, and 10.8% Fe polyisomaltosate, 5% Fe dextran, and 20% Fe (OH)3 complex with nitrilotri-propionic acid was studied by long and short term injection studies. Statistical analysis identified non-tumoral lesions and in the latter, spontaneous and induced tumors. The above products showed no promotive action on the spontaneous tumors of the mice in this series. In 6% of mice injected with the Fe hydroxide complex (Fe(OH)3), a local sarcomatous transformation was noted in relation to the extremely slow resorbability rate. The latency of 50% of the tumors in mice permitted to live as long as possible was used as the basis for evaluation of carcinogenic and co-carcinogenic properties of chemicals.

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