A Comparison of the Direct Effects and Adrenergic Blocking Activity of D/L- and D-propranolol on the Electrical and Mechanical Behaviour of Isolated Frog Ventricle
- 1 January 1969
- journal article
- research article
- Published by Oxford University Press (OUP) in Cardiovascular Research
- Vol. 3 (1) , 7-13
- https://doi.org/10.1093/cvr/3.1.7
Abstract
Propranolol was found to reduce the rate of depolarization, amplitude, and duration of the action potential recorded from frog ventricular myocardium. In these respects, D-propranolol was of similar potency to D/L-propranolol. However, D/L-propranolol was much more effective than the dextro isomer in blocking the increase in rate of depolarization, amplitude, and duration of the action potential caused by adrenaline; it was also much more potent than the dextro isomer in blocking the inotropic response to adrenaline.Keywords
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