Studies on ergothioneine. X. Effects of ergothioneine on the hepatic drug metabolizing enzyme system and on experimental hepatic injury in rats.
- 1 January 1983
- journal article
- research article
- Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN
- Vol. 31 (5) , 1676-1681
- https://doi.org/10.1248/cpb.31.1676
Abstract
When ergothioneine was administered to rats for 7 d [days], the pentobarbital sleeping time was reduced significantly. This action was specific to ergothioneine and was not shown by various ergothioneine-related compounds (Cys, glutathione, carnitine and His). This action of ergothioneine did not appear to be caused by induction of the drug-metabolizing enzyme system. The level of ergothioneine in the liver decreased markedly when phenobarbital or ethionine was administered to rats. Ergothioneine inhibited hepatic injury and significantly decreased the level of lipid peroxide induced by ethionine administration.This publication has 1 reference indexed in Scilit:
- Hepatic glutathione concentrations linked to ethionine toxicity in ratsBiochemical Journal, 1968