RNA Metabolism of Normal and Leukemic Leukocytes
Open Access
- 1 January 1967
- journal article
- research article
- Published by American Society of Hematology in Blood
- Vol. 29 (1) , 57-62
- https://doi.org/10.1182/blood.v29.1.57.57
Abstract
Ribonuclease has been partially purified from human leukocytes and its properties investigated. The enzyme has a pH optimum between 6 and 6.5. It is equally active with RNA prepared from various sources, attacking phosphodiester bonds adjacent to pyrimidine bases. Activity in myeloblasts or lymphocytes is about one-tenth that of mature granulocytes.This publication has 7 references indexed in Scilit:
- The Release of Ribonuclease into the Medium When Escherichia coli Cells Are Converted to SpheroplastsJournal of Biological Chemistry, 1964
- Studies on the Characterization of RibonucleasesJournal of Biological Chemistry, 1964
- Separation of Lymphocytes, Polymorphonuclear Leukocytes and Monocytes on Glass Columns, Including Tissue Culture ObservationsBlood, 1964
- STUDIES ON NORMAL AND LEUKEMIC LEUKOCYTES. IV. TETRAHYDROFOLATE-DEPENDENT ENZYME SYSTEMS AND DIHYDROFOLIC REDUCTASE*Journal of Clinical Investigation, 1963
- CHARACTERIZATION OF MAJOR COMPOUNDS IN RIBONUCLEASE T1 DIGESTS OF RIBONUCLEIC ACID .1. MONO-, DI-, AND TRINUCLEOTIDES1962
- Purification of viral RNA by means of bentoniteVirology, 1961
- STUDIES ON THE GROSS STRUCTURE, CROSS-LINKAGES, AND TERMINAL SEQUENCES IN RIBONUCLEASEJournal of Biological Chemistry, 1954