5-HT3 receptor antagonists attenuate dopamine-induced hyperactivity in the rat
- 1 September 1990
- journal article
- research article
- Published by Wolters Kluwer Health in NeuroReport
- Vol. 1 (1) , 77-80
- https://doi.org/10.1097/00001756-199009000-00021
Abstract
THE 5-HT3 receptor antagonists, ICS205–930, granisetron and zacopride, at low doses, inhibited the hyper-activity caused by a 13 day mesolimbic dopamine infusion in the rat. The antagonism decreased with the use of higher doses of the 5-HT3 receptor antagonists. The ability of low doses of the 5-HT3 receptor antagonists to inhibit dopamine-induced behavioural changes is similar to the inhibitory profile of known antipsychotic agents. It is suggested that 5-HT3 receptor antagonists may represent a new class of atypical antipsychotic agents.Keywords
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