Interferon‐γ‐independent CD8+ T cell‐mediated protective anti‐malaria immunity elicited by recombinant adenovirus
- 1 March 2000
- journal article
- research article
- Published by Wiley in Parasite Immunology
- Vol. 22 (3) , 157-160
- https://doi.org/10.1046/j.1365-3024.2000.00289.x
Abstract
Recombinant adenovirus, expressing the CS protein of Plasmodium yoelii, AdPyCS, was shown to induce a comparable degree of T cell-mediated protection against malaria as a single dose of irradiated P. yoelii sporozoites, causing inhibition of liver stage development. We now report that differently from sporozoite-induced immunity, interferon (IFN)-γ does not mediate the protective immunity induced by AdPyCS, since a similar degree of protection was observed in AdPyCS immunized mice lacking IFN-γ−/− and the IFN-γ receptor (IFN-γR−/−) compared to that in wild-type mice. Depletion of CD8+ T cells from these immunized mice almost completely abolished the AdPyCS-induced immunity, indicating that the immunization with AdPyCS induces CD8+ T cell-mediated protective anti-malaria immunity, which is independent of IFN-γ.Keywords
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