Effects of carbon disulphide on the liver of rats

Open Access

1 October 1969

journal article
research article
Published by BMJ in Occupational and Environmental Medicine

Vol. 26 (4) , 335-337
https://doi.org/10.1136/oem.26.4.335

Abstract

Bond, E. J., Butler, W. H., de Matteis, F., and Barnes, J. M. (1968).Brit. J. industr. Med.,26, 335-337. Effects of carbon disulphide on the liver of rats. Normal rats surviving a single oral dose of carbon disulphide (CS₂) show liver enlargement and depression of drug-metabolizing enzymes but no liver necrosis. If the drug-metabolizing enzymes are stimulated by phenobarbitone before exposure to CS_2, the LD₅₀ does not change but liver necrosis is produced.

Keywords

SURVIVING
CARBON DISULPHIDE
RATS
ENLARGEMENT
BARNES
BUTLER
INDUSTR
LD50
MATTEIS

This publication has 1 reference indexed in Scilit:

Biochemical changes in rat liver after administration of carbon disulphide, with particular reference to microsomal changes
Biochemical Pharmacology, 1969