Structure of ferrichrome-type siderophores with dissimilarN ?-acyl groups: Asperchrome B1,B2,3,D1, D2 and D3

Publisher Website
Google Scholar
Abstract
Asperchromes are a series of iron-chelating compounds which contain a cyclic hexapeptide backbone as in ferrichrome siderophores and differ from the latter in having heterogenous acyl groups in the ornithine side chains. The molecular structures of the asperchrome B and D series have been determined by1H- and13C-NMR spectroscopy; single-crystal X-ray diffraction was used to determine the detailed structural features of asperchrome B1 and asperchrome D1. Asperchrome B1 crystallizes in the triclinic space group P1 witha= 1.3143(5) nm,b=1.2200(5) nm,c=0.8949(3) nm,α=105.17(4)°,β=94.03(3)°, γ=109.65(3)°,V=1.2843 nm3,Z=1, ρ x =1.446 g cm−3. FinalR=0.054 for 4625 reflections measured at 138 K using MoKα. Asperchrome D1 crystallizes in the monoclinic space group P21 witha=1.2248(11) nm,b=1.3795(9) nm,c=1.3644(6) nm,β=93.24(6)°,V=2.3016 nm3,Z=2, ρ x =1.418 g cm−3. FinalR=0.110 for 3180 reflections measured at 138 K using MoKα radiation. The conformation of the molecular backbone and iron coordination geometry in both asperchrome B1 and D1 compare well with those observed in other known ferrichrome siderophores. The differences in the acyl groups are illustrated and the structural results are correlated with their iron transport properties.

This publication has 9 references indexed in Scilit: