Improved Schmidt Synthesis of 1,5-Disubstituted 1H-Tetrazoles from Ketones

1 January 1993

journal article
research article
Published by Georg Thieme Verlag KG in Synthesis

Vol. 1993 (12) , 1218-1220
https://doi.org/10.1055/s-1993-26027

Abstract

On treatment with an excess of sodium azide in the presence of titanium(IV) chloride in boiling acetonitrile, both aliphatic and aromatic ketones are smoothly converted to 1,5-disubstituted 1H-tetrazoles in high yields.

Keywords

TREATMENT
SODIUM
DISUBSTITUTED
SCHMIDT SYNTHESIS
TETRAZOLES
ACETONITRILE
CONVERTED
BOILING
ITALIC