Mono-Protected Diamines.N α-tert-Butoxycarbonyl α,ω-Alkanediamine Hydrochlorides from Amino alcohols
- 1 January 1990
- journal article
- research article
- Published by Georg Thieme Verlag KG in Synthesis
- Vol. 1990 (04) , 366-368
- https://doi.org/10.1055/s-1990-26879
Abstract
N α-tert-Butoxycarbonyl α,ω-alkanediamine hydrochlorides 3a-e are prepared from the amino alcohos in yields of 66-87%. Reaction of the free amine with di-tert-butyl dicarbonate gives the N-tert-Butoxycarbonylamino alcohol 1a-e. One-pot conversion to the azide 2a-e via the mesylate under phase-transfer conditions followed by hydrogenolysis in the presence of chloroform yields the title compounds.Keywords
This publication has 0 references indexed in Scilit: