Use of a pharmacological indicator to monitor compliance with thyroxine

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Abstract
Poor compliance with medication is often suspected, but difficult to confirm. The compliance of fourteen newly diagnosed hypothryroid patients was assessed using both TSH levels and low-dose phenobarbitone as a pharmacological marker. The study confirms the value of phenobarbitone as an indicator of compliance over a protracted period and suggests that it could be used to differentiate under-treatment from poor compliance.

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