Wortmannin, a PI3-Kinase Inhibitor: Promoting Effect on Insulin Secretion from Pancreatic β Cells through a cAMP-Dependent Pathway
- 21 April 2000
- journal article
- Published by Elsevier in Biochemical and Biophysical Research Communications
- Vol. 270 (3) , 798-805
- https://doi.org/10.1006/bbrc.2000.2514
Abstract
No abstract availableKeywords
This publication has 28 references indexed in Scilit:
- Leptin inhibits insulin secretion by activation of phosphodiesterase 3B.Journal of Clinical Investigation, 1998
- Potentiation of Insulin-Induced Phosphatidylinositol-3 Kinase Activity by Phorbol Ester Is Mediated by Protein Kinase CϵCellular Signalling, 1998
- Glucose-Dependent Insulinotropic Polypeptide Stimulates Insulin Secretion via Increased Cyclic AMP and [Ca2+]iand a Wortmannin-Sensitive Signalling PathwayBiochemical and Biophysical Research Communications, 1996
- Cyclic AMP Phosphodiesterases of Human and Rat Islets of Langerhans: Contributions of Types III and IV to the Modulation of Insulin SecretionBiochemical and Biophysical Research Communications, 1995
- Wortmannin and Its Structural Analogue Demethoxyviridin Inhibit Stimulated Phospholipase A2 Activity in Swiss 3T3 CellsJournal of Biological Chemistry, 1995
- An Inhibitory Role for Phosphatidylinositol 3-Kinase in Insulin Secretion from Pancreatic B Cell Line MIN6Biochemical and Biophysical Research Communications, 1995
- Hamster Gastric Inhibitory Polypeptide Receptor Expressed in Pancreatic Islets and Clonal Insulin-Secreting Cells: Its Structure and Functional PropertiesBiochemical and Biophysical Research Communications, 1994
- Wortmannin, an inhibitor of phospholipase D activation, selectively blocks major histocompatibility complex class II‐restricted antigen presentationEuropean Journal of Immunology, 1994
- Essential role of phosphatidylinositol 3‐kinase in insulin‐induced activation and phosphorylation of the cGMP‐inhibited cAMP phosphodiesterase in rat adipocytes studies using the selective inhibitor wortmanninFEBS Letters, 1994
- Feedback inhibition of insulin gene expression by insulin.Journal of Clinical Investigation, 1992