Temperature Level and the Growth of Embryo and Tumor of Tumor-Bearing Eggs

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Abstract
Rat and mouse tumor tissue was maintained continuously in eggs for over 4 yrs. by the yolk sac method. This type of inoculation enables the tumor and chick to grow together sharing a common blood supply and with a minimum of interference with each other. The method insures 100% takes and a tumor growth comparable to that of transplants in the host animal. These egg-grown tumors were used in a study of the comparative reactions of tumor and chick tissue to temps. above and below that required for normal incubation (99-100[degree]F). A total of 1,179 tumor-bearing eggs were used in the investigation. Eggs incubated at 96-97[degree]F produced embryos and tumors which averaged in wt. 85.6 and 60% respectively as compared to the controls. Eggs incubated at 103-104[degree]F produced embryos and tumors which averaged in wt. 88.1 and 50% of the controls. The tumor tissue was evidently more sensitive than the embryo tissue to the changes in temp. levels.

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