Renal Function After Bilateral Denervation of the Kidney in Normal Dogs

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Abstract
Three dogs, placed in metabolism cages with intake of food and fluid constant, were observed for 5 mos., including output of urine in 24 hrs., excretion of phenolsulphonephthalein, response of the kidneys to ingestion of water, response to metaphyllin administered intravenously, and changes in blood urea, creatinine, sugar, chlorides, and hemoglobin. Bilateral denervation of the kidneys, after a period of observation, was done by stripping the renal vessels of all nerves. Health of the animals was not impaired. Renal overfunction was produced, and lasted at least 2 mos. At the end of 5 mos., the only evidence of increased function was increased diuresis following ingestion of water. There were no significant changes in blood chemistry.

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