Functional alterations of the endoplasmic reticulum and the detoxification systems during diethyl‐nitrosamine carcinogenesis in rat liver

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Abstract
The mixed‐function oxidase system shows a number of variations in the liver of diethyl‐nitrosamine (DEN) treated rats. These include a decrease of the cytochrome P450 content and of the aminopyrine demethylase activity both in the hyperplastic nodules and in the hepatoma. Processes of detoxification, such as the glutathione system, show some modifications. These alterations are in accordance with the decrease of glutathione peroxidase and the increase of γ‐glutamyltranspeptidase during diethyl‐nitrosamine carcinogenesis.