Potential Use of Vaccines Based on Cell-Wall-Defective or -Deficient (L-form)Aeromonas salmonicidafor the Control of Furunculosis

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Abstract
In laboratory-based experiments with Atlantic salmon Salmo salar and rainbow trout Oncorhynchus mykiss, the efficacy of vaccines composed of forms of Aeromonas salmonicida that have defective or deficient cell walls (L-forms) was compared with the efficacy of vaccines of formalin-inactivated whole cells grown in standard or in iron-limiting conditions. LysozymeEDTA-induced L-form preparations conferred more protection than did inactivated whole cells or benzylpenicillin-induced L-forms after challenge with two virulent cultures of A. salmonicida

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