Transplantation of Carbon Tetrachloride-Induced Hepatomas in Mice2

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Abstract
Five carbon tetrachloride-induced hepatomas from a mouse that was killed 8 months after the last administration of CCl4 were successfully transplanted to mice of the same strain, but transplantations of primary tumors from mice whose CCl4 treatments ceased after 11 weeks or less were not successful. This suggests that there is a progressive increase in the capacity for autonomous growth in the primary hepatoma. One of the CCl4-induced hepatomas maintained by serial, intrasplenic transplantations is now in its fifteenth generation. During passage through successive hosts there have been only slight morphological changes, but a gradual decrease in time from 4 months to 2 months between transplantations has occurred.

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